Back to Globe
Mpox Outbreak in Africa
Health & Pandemics

Mpox Outbreak in Africa

Severity
8/10
Impact
21.3Kpeople
Trend
worsening
Region
Democratic Republic of the Congo, Burundi, Kenya, Rwanda, Uganda, Malawi, Mozambique, Republic of Congo, South Africa, Tanzania, Zambia, Madagascar
Mpox remains an active public health crisis in Africa, with the latest WHO reporting showing continued transmission across the continent in 2026. WHO’s 14 September 2026 situation report said it covered Africa’s epidemiological situation through 16 August 2026, and WHO Africa reported that between July 2025 and June 2026, mpox caused 21,306 confirmed cases and 121 deaths across 30 countries, with a case fatality ratio of 0.6%. The outbreak is still concentrated in the Democratic Republic of the Congo, but transmission has also been reported in Burundi, Kenya, Rwanda, Uganda, Malawi, Mozambique, Republic of Congo, South Africa, Tanzania, Zambia, and Madagascar. WHO also reported that in the six weeks from 6 July to 16 August 2026, 11 African countries recorded 1,153 confirmed cases and seven deaths, showing that active transmission persisted in multiple countries rather than being confined to a single hotspot. Clade Ib remains the key concern because WHO and CDC updates indicate that it continues to drive sustained spread in Central and Eastern Africa, with community transmission documented in several countries. WHO’s broader 2026 surveillance also noted that Africa accounted for most confirmed global cases in May 2026, underscoring that the continent remains the center of the epidemic.

Recent Developments

0114 Sep 2026: WHO issued External Situation Report #69 covering Africa through 16 Aug 2026 and global data through 31 Jul 2026.

02July-Aug 2026: WHO reported 1,153 confirmed cases and seven deaths across 11 African countries in six weeks.

032026 WHO surveillance showed Africa accounted for 76% of confirmed global mpox cases in May 2026 (1,408 of 1,844 cases).

Interventions

  • WHO regional outbreak surveillance and operational response reporting for the African Region.
  • Continental and national mpox response activities in affected African countries, including case detection, contact tracing, and outbreak management.

What Works

  • Rapid case detection, isolation, and contact tracing to interrupt transmission chains.
  • Targeted outbreak response in the most affected countries, especially the DRC and neighboring countries where clade Ib is circulating.

How to Help

  • Donate to organizations supporting outbreak surveillance, diagnostics, and response in affected African countries.
  • Support humanitarian and public health NGOs working on infection prevention and community outreach.
  • Advocate for sustained funding for mpox surveillance, vaccines, and health-system support.

Make an Impact

Donate directly to 3 verified organizations working on this crisis. Every contribution makes a difference.

Donate to Organizations ↓

Coming soon: one-click donations distributed across all organizations via our impact protocol.

Raise Awareness

Can't donate? You can still make a huge impact. Join others in amplifying this cause globally by sharing it with your network.

Verified Organizations

Organizations Helping(23)

Africa CDC is involved in continental cholera coordination with UNICEF and WHO through the Continental Task Force for Cholera. Its role is to help align national responses, reduce preventable deaths, and support elimination efforts through coordinated surveillance, response planning, and outbreak control actions alongside partners.

WHO maintains global mpox surveillance, provides response guidance, supports diagnostics and vaccine access via the International Coordinating Group (ICG) for mpox vaccines, and evaluates rapid diagnostic tests. In the African Region, they support a continental response across all pillars including surveillance, diagnostics in most countries, and vaccine delivery to 16 countries for at-risk populations. They also focus on communication, community engagement, case detection, treatment, laboratory confirmation, transmission containment, health supplies, and health worker protection.

IDSA tackles the mpox crisis through expert analysis and advocacy, publishing detailed reports on the African epidemic including clade Ib dynamics, calling for urgent increases in vaccine and diagnostic access, recommending research into antiviral treatments and mutation risks, and urging global funding for surveillance, contact tracing, and community health worker deployment in epicenters like DRC, Malawi, and Sierra Leone.

CDC supports Myanmar through public health collaboration that strengthens outbreak detection, investigation, and response capacity. Its work includes field epidemiology training, surveillance improvements, laboratory capacity, and partnership with the Ministry of Health to better identify and control infectious disease outbreaks, including vaccine-preventable diseases such as measles.

Sources & Citations

Related Crises